Dose reduction for MedX was recommended because in the older people there is a much larger danger for problems which are medicine related. The drug sometimes gets accumulated in their body and cause toxicity. According to the properties of MedX, it can be seen that after the first pass metabolism, its bioavailability reduces to 10% and being a water-soluble drug, it easily pass through the kidney and gets excreted out. Therefore, if a small dose of medicine is provided then, it will not affect the medicine concentration in the patient body that much. However, a large dose of medicine will eventually be excreted out and an only small concentration of it would remain in the body (Brahma et al., 2013). The age-related changes to the pharmacokinetics of the drugs are reduction in the functioning of liver and kidney because, in old people, the functioning of these two organs gets deducted due to which drugs remain in the body for longer period of time as it does not get excreted out. Therefore, in the plasma, the concentration of the drug rises. With that, absorption by small intestine also gets reduced with age in people. Thus, drugs do not get absorbed into the body properly and remain in the blood plasma and their concentration increases in it. In addition to that, in ageing adults, there is a problem in drug distribution. The water-soluble drugs or medicines generally have low distribution volume which results in an increased level of serum in old people (Hubbard et al., 2013).
Brahma, D. K., Wahlang, J. B., Marak, M. D., & Ch Sangma, M. (2013). Adverse drug reactions in the elderly. Journal of Pharmacology & Pharmacotherapeutics, 4(2), 91–94. https://doi.org/10.4103/0976-500X.110872
Hubbard, R. E., O’Mahony, M. S., & Woodhouse, K. W. (2013). Medication prescribing in frail older people. European Journal of Clinical Pharmacology, 69(3), 319-326. https://doi.org/10.1007/s00228-012-1387-2
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