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  • Subject Name : Nursing

Understanding of The Critical Review of Clinical Study

Research paper under analysis: “24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain”

Reference: “Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., ... & Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5), 1485-1496.”

The abstract of this paper provides a clear and distinct summary of the research conducted by the authors. The abstract has been provided with clear sections of background, objective, design and setting, study participants, interventions, main outcome measures, results, and conclusion. The aim of the research coherently relates to the aim of the study. The background identifies that collagen hydrolysate is commonly used as a nutritional supplement that is used for anabolic effect on the cartilage tissue and is therefore found to be effective for patients with osteoarthritis. The objective of the study is indicated that is, to “investigate the effect of collagen hydrolysate on activity-related joint pain in athletes who are physically active and have no evidence of joint disease”.

A prospective, placebo-controlled, randomized, double-blind study has been conducted at the Penn State University with the inclusion of parameters like joint pain, inflammation, and mobility with a visual analogue scale for a time frame of 24 weeks. The study participants have been clearly defined with 147 subjects with 72 males and 75 females that were randomly assigned to groups that received the collagen hydrolysate formulation. The primary parameter for the analysis was the change in analogue scales from the baseline for the concerned parameters. The results indicated that the six parameters presented with significant results in contrast to the placebo effect. The study indicates that the clinical trial 24 of weeks indicated a positive response in the athletes who were provided supplemented with the solution of collagen hydrolase.

The primary problem associated with the abstract was the lack of information about the ethical considerations of this research. Even when the sections of the study were clearly defined, the study failed to address the statistical tool used for the analysis. The age criteria for inclusion or exclusion have not to be mentioned. The analysis was also conducted only for individuals from 97 of 147 subjects making preventing generalization of the approach. The cause of withdrawal and the inclusion and the exclusion criteria were not mentioned in the study. However, the parameters were described clearly. The objective and methodology of the study were indicated in the research.

While reading the paper, I will be looking forward to studying the impact of collagen hydrolase on the individual parameters to understand its efficacy. I will also be looking forward to see the impact of age and gender differentiation, if any, in the study. I will also be looking forward to understand the mechanism of action of this medication and how it helps the people with osteoarthritis in contrast to the placebo effect.

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